Christopher Brett is an Associate Professor of Biology and Canada Research Chair at Concordia University and Adjunct Professor of Anatomy & Cell Biology at McGill University in beautiful Montréal, QC, Canada. His research program is dedicated to understanding how the endocytic system functions and how defects in this pathway lead to symptoms associated with neurodevelopmental disorders like autism and lysosomal storage diseases.
The ion and membrane transport laboratory
Specializing in both yeast and neural cell biology, our lab is dedicated to understanding how sodium hydrogen exchangers (ion transporters) and the fusion machinery (responsible for membrane transport or trafficking) work together in the endocytic system to control protein degradation, to determine organelle size, shape and number, and to allow synaptic pruning in neurons. Mutations in genes responsible for endocytosis - such as NHE9, a sodium hydrogen exchanger - are linked to autism spectrum disorders and ADHD. By determining the effects of these mutations on endocytic function, we aim to uncover the cellular basis of these diseases - a necessary step towards developing treatments. Our lab is affiliated with the Groupe d'Étude des Protéines Membranaires (GÉPROM) and Dr. Brett co-directs the Centre for Microscopy and Cellular Imaging at Concordia (CMCI). Check out the research page for more details, and have a look at the publications page for a complete list of research articles from the lab.
Research opportunities updated Aug 2015
NEW GRADUATE STUDENT POSITIONS ARE AVAILABLE IN 2016!!!
Applicants must have experience studying endocytosis, membrane fusion, or ion transport in yeast. Check out the opportunities page for details.
Laboratory news updated Sep 2014